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| Research article summary (published 23 Jun 2003): |
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Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.
Full Abstract
The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to caffeine and polymorphisms in the A1 and A2a adenosine receptor genes. Healthy, infrequent caffeine users (N=94) recorded their subjective mood states following a 150 mg oral dose of caffeine freebase or placebo in a double-blind study. We found a significant association between self-reported anxiety after caffeine administration and two linked polymorphisms on the A2a receptor gene, the 1976C>T and 2592C>Tins polymorphisms. Individuals with the 1976T/T and the 2592Tins/Tins genotypes reported greater increases in anxiety after caffeine administration than the other genotypic groups. The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.
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Author information
Author/s: Alsene, Karen (K); Deckert, Jürgen (J); Sand, Philipp (P); de Wit, Harriet (H);
Affiliation: Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA.
Grants: DA02812 (Agency:United States NIDA)
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology), published in United States. (Language: eng)
Reference: 2003-Sep; vol 28 (issue 9) : pp 1694-702
Dates: Created 2003/08/22; Completed 2003/10/06; Revised 2007/11/14;
PMID: 12825092, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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