Research article summary:

AMPA receptor trafficking and synaptic plasticity.

Abstract Extract:
Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny ... (Full abstract text below)

Published 2002 in Journal: Annu Rev Neurosci (Language : eng)

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1. Annu Rev Neurosci. 2002 ;25():103-26

AMPA receptor trafficking and synaptic plasticity.

Malinow R, Malenka RC

Cold Spring Harbor Laboratory, New York 11724, USA. malinow@cshl.org

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.

PMID : 12052905 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Roberto	Malinow	R
Robert C	Malenka	RC

Affiliation: Cold Spring Harbor Laboratory, New York 11724, USA. malinow@cshl.org

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