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| Research article summary (published 26 Feb 2002): |
Aging and neuronal plasticity: lessons from a model.
Full Abstract
In spite of many well-documented examples of age-related reductions in neuronal plasticity, the causes of such changes remain largely unknown. One example of age-reduced plasticity involves an aberrant sprouting response of mature rat sympathetic neurons into the CNS (hippocampal formation). This phenomenon has proven to be useful for exploring the relative contribution of target aging (extrinsic influences) versus neuronal aging (intrinsic influences) to reduced sprouting. Aged sympathetic neurons mount a robust growth response when confronted with young target tissue or when exposed to exogenous trophic factor in vivo. In contrast, the aged target tissue (the hippocampal formation in this example) exhibits reduced receptivity for sympathetic sprouting. This change in the target does not appear to be due to alterations in baseline levels of trophic or substrate support for axonal growth. Rather, aging appears to dampen the consequences of target denervation so that the aged target elicits less sprouting. Age-related reductions in neuronal sprouting are speculated to reflect increasing commitment to information storage at the expense of neuronal plasticity.
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Author information
Author/s: Crutcher, Keith A (KA);
Affiliation: Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515, USA. crutchka(-atsign-)email.uc.edu
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Autonomic neuroscience : basic & clinical (Auton Neurosci), published in Netherlands. (Language: eng)
Reference: 2002-Feb; vol 96 (issue 1) : pp 25-32
Dates: Created 2002/03/25; Completed 2002/12/03; Revised 2006/11/15;
PMID: 11911499, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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