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Does age, sex, or ACE genotype affect glucose and insulin responses to strength training?
Full Abstract
The purpose of the present study was to determine whether age, sex, or angiotensin I-converting enzyme (ACE) genotype influences the effects of strength training (ST) on glucose homeostasis. Nineteen sedentary young (age = 20-30 yr) men (n = 10) and women (n = 9) were studied and compared with 21 sedentary older (age = 65-75 yr) men (n = 12) and women (n = 9) before and after a 6-mo total body ST program. Fasting insulin concentrations were reduced in young men and in older men with ST (P < 0.05 in both). In addition, total insulin area under the curve decreased by 21% in young men (P < 0.05), and there was a trend for a decrease (11%) in older men (P = 0.06). No improvements in insulin responses were observed in young or older women. The ACE deletion/deletion genotype group had the lowest fasting insulin and insulin areas under the oral glucose tolerance test (OGTT) curve before training (all P < 0.05), but those with at least one insertion allele had a trend for a greater reduction in total insulin area than deletion homozygotes (P = 0.07). These results indicate that ST has a more favorable effect on insulin response to an OGTT in men than in women and offer some support for the hypothesis that ACE genotype may influence insulin responses to ST.
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Author information
Author/s: Hurlbut, D E (DE); Lott, M E (ME); Ryan, A S (AS); Ferrell, R E (RE); Roth, S M (SM); Ivey, F M (FM); Martel, G F (GF); Lemmer, J T (JT); Fleg, J L (JL); Hurley, B F (BF);
Affiliation: Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, Maryland 20742, USA.
Grants: AG-00268 (Agency:United States NIA) ; AG-05893 (Agency:United States NIA) ; AG-1620501 (Agency:United States NIA) ; AG-42148 (Agency:United States NIA)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol), published in United States. (Language: eng)
Reference: 2002-Feb; vol 92 (issue 2) : pp 643-50
Dates: Created 2002/01/17; Completed 2002/04/08; Revised 2007/11/14;
PMID: 11796676, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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