Artificial Intelligence

61.

Providing concept-oriented views for clinical data using a knowledge-based system: an evaluation.

OBJECTIVE: Clinical information systems typically present patient data in chronologic order, organized by the source of the information (e.g., laboratory, radiology). This study evaluates the functionality and utility of a knowledge-based system that ...
Qing Zeng, James J Cimino, Kelly H Zou (J Am Med Inform Assoc, 200205-06)
providing-concept-oriented-views-clinical-data-knowledge-based-system.asp

62.

Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.

OBJECTIVE: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of ...
Melissa Frumin, Polina Golland, Ron Kikinis, Yoshio Hirayasu, Dean F Salisbury, John Hennen, Chandlee C Dickey, Mark Anderson, Ferenc A Jolesz, W Eric L Grimson, Robert W McCarley, Martha E Shenton (Am J Psychiatry, 200205)
shape-differences-corpus-callosum-first-episode-schizophrenia-first.asp

63.

Knowledge-based approaches in the design and selection of compound libraries for drug discovery.

In the past decade, the pharmaceutical industry has realized the increasing significance of impacting the early phase hit-to-lead development in the drug discovery process. In particular, knowledge-based approaches emerged and evolved to address a ...
Vellarkad N Viswanadhan, Chenera Balan, Christopher Hulme, Janet C Cheetham, Yaxiong Sun (Curr Opin Drug Discov Devel, 200205)
knowledge-based-approaches-design-selection-compound-libraries-drug.asp

64.

Support vector machines with selective kernel scaling for protein classification and identification of key amino acid positions.

MOTIVATION: Data that characterize primary and tertiary structures of proteins are now accumulating at a rapid and accelerating rate and require automated computational tools to extract critical information relating amino acid changes with the spectrum ...
Nela Zavaljevski, Fred J Stevens, Jaques Reifman (Bioinformatics, 200205)
support-vector-machines-selective-kernel-scaling-protein.asp

65.

Medical image segmentation with knowledge-guided robust active contours.

Medical image segmentation techniques typically require some form of expert human supervision to provide accurate and consistent identification of anatomic structures of interest. A novel segmentation technique was developed that combines a ...
Riccardo Boscolo, Matthew S Brown, Michael F McNitt-Gray (Radiographics, 200203-04)
medical-image-segmentation-knowledge-guided-robust-active-contours.asp

66.

Efficiency and safety of chemotherapy plans for children: CATIPO--a nationwide approach.

Chemotherapy is an important component of childhood cancer treatment. Due to the intensity of this therapy, an error in calculating the dosage of the cytostatic drugs would have severe consequences. Therefore, a computer-aided therapy planning system in ...
Petra Knaup, Timm Wiedemann, Andreas Bachert, Ursula Creutzig, Reinhold Haux, Freimut Schilling (Artif Intell Med, 200203)
efficiency-safety-chemotherapy-plans-children-catipo-nationwide.asp

67.

Development and evaluation of VIE-PNN, a knowledge-based system for calculating the parenteral nutrition of newborn infants.

Calculating the daily changing composition of parenteral nutrition for small newborn infants is troublesome and time consuming routine work in neonatal intensive care. The task needs expertise and experience and is prone to inherent calculation errors. ...
Werner Horn, Christian Popow, Silvia Miksch, Lieselotte Kirchner, Andreas Seyfang (Artif Intell Med, 200203)
development-evaluation-vie-pnn-knowledge-based-system-calculating.asp

68.

An interactive framework for an analysis of ECG signals.

In this study, we introduce and discuss a development of a highly interactive and user-friendly environment for an ECG signal analysis. The underlying neural architecture being a crux of this environment comes in the form of a self-organizing map. This ...
Giovanni Bortolan, Witold Pedrycz (Artif Intell Med, 200202)
interactive-framework-analysis-ecg-signals.asp

69.

Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge.

The ability to investigate the transcription of thousands of genes concurrently by using DNA microarrays offers both major scientific opportunities and significant analytical challenges. Here we describe GABRIEL, a rule-based system of computer programs ...
Kuang-Hung Pan, Chih-Jian Lih, Stanley N Cohen (Proc Natl Acad Sci U S A, 200202)
analysis-dna-microarrays-algorithms-employ-rule-based-expert-knowledge.asp

70.

The potential of latent semantic analysis for machine grading of clinical case summaries.

OBJECTIVE: This paper introduces latent semantic analysis (LSA), a machine learning method for representing the meaning of words, sentences, and texts. LSA induces a high-dimensional semantic space from reading a very large amount of texts. The meaning ...
Walter Kintsch (J Biomed Inform, 200202)
potential-latent-semantic-analysis-machine-grading-clinical-case.asp